Natural Compounds Chemistry

Actual modern research tasks being solved at the department:

  • synthesis of modern bioregulators for the creation of new generation medications.
  • development of schemes for total synthesis of modified steroidal hormones and investigation of mechanisms of their action.
  • development of synthetic pathways to medications for the treatment of breast cancer, prostate cancer, endometriosis and many others disorders.
  • development of medications for the treatment of cardio-vascular diseases, osteoporosis, neurodegenerative disorders.
  • creation of diagnostic tools for early stages of breast cancer, prostate cancer, endometriosis and other disorders.
  • investigation of biological activities on cells and animal models.

The department is unique in Russian Federation where this direction exists.

Investigation of triterpenoids (establishment of their structure and investigation of biological activity) - head - associate professor Alla D. Zorina.

The group of peptide synthesis (the former head – Professor M.I. Titov) investigates natural peptides and its analogues, as well as their structure-biological activity relationship. Such compounds are significant both for diagnosis of different disorders and for practical medicine. At different times insulin, oxytocin, luliberin, calcitonin, delta sleep-inducing peptides, bombesin and their analogues were synthesized. For their work on synthesis of various peptide modulators M.I. Titov and Z.D. Bespalova were awarded the State Prize.

The following courses are being lectured only at the department:

  • «Bioorganic Chemistry»,
  • «Heterocyclic steroidal hormones»,
  • «Receptors of medications»,
  • «Chemistry of natural compounds»,
  • «Chemistry of peptides»,
  • «Chemistry of heterocyclic compounds»,
  • «Pharmaceutical chemistry»,

as well as laboratory courses. Diploma and PhD theses are devoted to urgent problems of bioorganic chemistry.

Some lecture courses are being lectured on English or French.

The department has collaboration with many National and International Research groups and Institutes (Germany, Sweden, Finland, USA, England).


Department Members

Selected Publications

Patents

Conferences

History of the Department