Laboratory of Biomedical Chemistry

Biofunctional Scaffolds for Tissue Engineering

Group members

Group leader

PhD, Associate Professor

PhD, Senior Researcher

PhD student

Prof. MD Mikhail Serdobintsev (Department of Phthysioosteology and orthopaedy) and Prof. MD Tatiana Vinogradova (Laboratory of experimental tuberculosis and new medical technologies), Institute of Phthisiopulmonology RAS;
Prof. Thomas Scheper and Dr. Antonina Lavrentieva, Institute of Technical Chemistry Leibniz University of Hannover;
Laboratory of polymer carriers and sorbents for biotechnology and Laboratory of polymer biomaterials and systems Institute of Macromolecular Compounds RAS.

supermacroporous matrices based on polymers of different nature to be used as scaffold for tissue engineering;
3D-printing of complex polymer materials;
modification of the polymeric materials surface with biomolecules of different nature and functionality in order to regulate cells adhesion, migration, proliferation and differentiation;
construction of scaffolds, which are able to release growth factors and anti-inflammatory agents in a controlled manner;
in vitro and in vivo testing of the obtained materials.

Korzhikov 3D

3D printer GeSim BioScaffolder^® in the Laboratory of polymer biomaterials and systems at the Institute of Macromolecular Compounds RAS

Participation into the project «Development of biocompatible materials based on chemically modified cellulose» within Megagrant of Russian Government (agreement № 14.W03.31.0014). The Laboratory within this Megagarnt is headed by Prof. Dr. Mikko Karttunen.
RSF-DFG grant application together with the Institute of Technical Chemistry at Leibniz University of Hannover. The grant theme is “Biodegradable scaffolds for bone tissue engineering: materials with adjustable mechanical and biofunctional properties, capable of controlled release of osteogenic factors”.

Averianov I., Korzhikov-Vlakh V.A., Moskalenko Yu., Smirnova V., Tennikova T. One-pot synthesis of poly(lactic acid) with terminal methacrylate groups for the adjustment of mechanical properties of biomaterials. Mendeleev Communications. 2017. V. 27. P.574-576.
Korzhikov-Vlakh V., Averianov I., Sinitsyna E., Nashchekina Y., Polyakov D., Guryanov I., Lavrentieva A., Raddatz L., Korzhikova-Vlakh E., Scheper T., Tennikova T. Novel pathway for efficient covalent modification of polyester materials of different design to prepare biomimetic surfaces. Polymers (Basel). 2018. 10.
Averianov I.V., Stepanova M.A., Gofman I.V., Nikolaeva A.L., Korzhikov-Vlakh V.A., Karttunen M., Korzhikova-Vlakh E.G. Chemical modification of nanocrystalline cellulose for enhanced interfacial compatibility with poly(lactic acid). Mendeleev Communications. 2019. V.29. P.220-222.