Department of Macromolecular Compounds Chemistry
Applied polymer systems
Research Team
The head of the research team — Pavel Chelushkin
Members
- ChelushkinPavel, PhD, Associate Professor; This email address is being protected from spambots. You need JavaScript enabled to view it.
- Elistratova Anastasia; alumni of the PhD program 2024
- Zharskaya Nina; Master's student, 1st year of study
- Kalinin Nikita; Master's student, 1st year of study
- Chuikov Nikita; undergraduate (bachelor) student, 4th year
Research
Themainfocusofthegroupisresearchonvariouspolymericandbiopolymericcarrierssuchasalbumin (1), blockcopolymermicelles (2), andliposomes (3).
The works in this area were supported by the RFBR grant and are supported by the RSF grant
1. RSF Project #24-23-00275 (2024–2025); PI - P.S. Chelushkin
Aggregation-Induced Phosphorescence Ignition of Organometallic Complexes in Block Copolymer Micelles
The project is devoted to systematic investigation of the effect of aggregation-induced phosphorescence emission/enhancement (AIPE) on the example of three series of organometallic phosphorescent complexes based on platinum(II), gold(III) and iridium(III) embedded into block copolymer micelles of the «core-shell» structural type based on amphiphilic diblock copolymers with a variable hydrophobic block and a hydrophilic block based on polyethylene glycol.The major feature of the project is in the idea of spatial localization of the AIPE effect in a strictly limited volume of polymer nanoparticles.
2. RFBR-MOST Project # 20-53-S52001 (2020–2022 г.); PI - P.S. Chelushkinb
Phosphorescent polymer micelles for lifetime oxygen biosensing
Within the scope of this project, we suggest the approach that simultaneously provides dispersion stability for phosphorescent transition metal complexes in aqueous media and protects their lifetimes from the microenvironment by embedding them into spherical block copolymer micelles with a core-shell morphology. In such micelles composed from amphiphilic diblock copolymers, the core is formed by hydrophobic blocks and is able to solubilize various water-insoluble molecules, whereas the hydrophilic polymer chains of the shell stabilize the micelles in water and prevent the contact of hydrophobic phosphors with bio-macromolecules owing to the steric barrier. At the same time, the relatively small sizes of luminescent micelles (total dimensions - 20-50 nm, core sizes - 10-15 nm) will ensure the diffusion of oxygen and thus retain the sensitivity of phosphorescence lifetime with respect to this analyte.
Publications
- Elistratova, A. A., Gubarev, A. S., Lezov, A. A., Vlasov, P. S., Solomatina, A. I., Liao, Y.-C., Chou P.-T.,Tunik S. P., Chelushkin P. S., Tsvetkov, N. V. AmphiphilicDiblockCopolymersBearingPoly(EthyleneGlycol) Block: HydrodynamicPropertiesinOrganicSolventsandWaterMicellarDispersions, EffectofHydrophobicBlockChemistryonDispersionStabilityandCytotoxicity// Polymers, 2022, 14(20), 4361. DOI: 10.3390/polym14204361
- Zharskaia, N. A., Solomatina, A. I., Liao, Y.-C., Galenko, E. E., Khlebnikov, A. F., Chou, P.-T., Chelushkin P. S., Tunik, S. P. Aggregation-InducedIgnitionofNear-InfraredPhosphorescenceofNon-Symmetric [Pt(C^N*N’^C’)] ComplexinPoly(Caprolactone)-BasedBlockCopolymerMicelles: EvaluatingtheAlternativeDesignofNear-InfraredOxygenBiosensors// Biosensors, 2022, 12(9), 695. DOI: 10.3390/bios12090695
- Elistratova, A.A., Kritchenkov, I.S., Lezov, A.A., Gubarev A.S., Solomatina, A.I., Kachkin, D.V., Shcherbina, N.A., Yu-Chan Liao, Yi-Chun Liu, Ya-Yun Yang, Tsvetkov, N.V., Chelushkin, P. S., Pi-Tai Chou, Tunik, S.P. Lifetime oxygen sensors based on block copolymer micelles and non-covalent human serum albumin adducts bearing phosphorescent near-infrared iridium(III) complex // Eur. Polym. J., 2021, 159, 110761. DOI: 10.1016/j.eurpolymj.2021.110761