Laboratory of Biomedical Chemistry
Laboratory of biomaterials 
LABORATORY STAFF
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Head of the lab PhD, Associate Professor Viktor Korzhikov-Vlakh Office 4209, This email address is being protected from spambots. You need JavaScript enabled to view it. |
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PhD, senior reseacher Ekaterina Sinitsyna Office 4210 |
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PhD, senior reseacher Evgenia Korzhikova-Vlakh Office 4209 |
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PhD student, research engineer Leonovich Maria |
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PhD student, research engineer Dzhuja Apolinaria |
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PhD student, research engineer Irina Bagayeva |
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Engineer Anastasia Petrova |
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Research technician, master student Alikparova Elina |
Directions of Research
The scientific activity of the laboratory is focused on the creation and testing of materials for biomedical applications. Currently, research in the laboratory is focused on the development of new drug delivery systems and scaffolds for tissue engineering based on natural and synthetic polymers. To obtain target systems, the laboratory uses methods of synthesis and modification of polymers, as well as various methods of formation of materials of different size and morphology: nanoparticles, microparticles, films, macroporous matrixes, etc. The laboratory uses the methods of synthesis and modification of polymers. Biological testing of the obtained materials using cell cultures takes place directly in the laboratory itself in specially equipped clean rooms.
The scientific and educational activities of the laboratory are focused on the following areas of biomedicine:
- controlled release and drug delivery systems;
- delivery systems for therapeutic proteins and genetic constructs;
- biomaterials for tissue engineering;
- synthesis of polymers for biomedical applications.
3D printer GeSim BioScaffolder® in the Laboratory of polymer biomaterials and systems at the Institute of Macromolecular Compounds RAS
Grants
RSF grant “Polymeric delivery systems of antibiotics to improve the effectiveness of treatment of tuberculosis of different localization” № 24-15-00185 (project leader - Associate Professor V.A. Korzhikov-Vlakh).
Large scientific project of the Ministry of Education and Science of the Russian Federation “Polymers for Sustainable Development” (project leader - Academician V.Y. Kukushkin, direction head - Professor T.B. Tennikova)
Publications 2020-2024
- IlyaS. Kritchenkov, DaniilD. Zhukovsky, AbdelrahmanMohamed, ViktorA. Korzhikov-Vlakh, TatianaB. Tennikova, AntoninaLavrentieva, ThomasScheper, VladimirV. Pavlovskiy, VitalyV. Porsev, RobertA. Evarestov, SergeyP. Tunik. Functionalized Pt(II) and Ir(III) NIR Emitters and Their Covalent Conjugates with Polymer-Based Nanocarriers. Bioconjugate Chem. 2020. 31, 5, 1327-1343. https://pubs.acs.org/doi/abs/10.1021/acs.bioconjchem.0c00020. DOI: 10.1021/acs.bioconjchem.0c00020. IF JCR = 6.069, Q1.
- Korzhikov-Vlakh V., Katernuk I., Pilipenko I., Lavrentieva A., Guryanov I., Sharoyko V., Manshina A.A., Tennikova T.B. Photosensitive Poly-L-lysine/Heparin Interpolyelectrolyte Complexes for Delivery of Genetic Drugs. Polymers 2020, 12, 1077. https://doi.org/10.3390/polym12051077, https://www.mdpi.com/2073-4360/12/5/1077; IF JCR = 4.967, Q1.
- Pilipenko I.M., Korzhikov-Vlakh V.A., Zakharova N.V., Urtti A., Tennikova T.B. Thermo- and pH-sensitive glycosaminoglycans derivatives obtained by controlled grafting of poly(N-isopropylacrylamide). Carbohydrate Polymers. 2020, 248, 116764. https://www.sciencedirect.com/science/article/pii/S0144861720309371. DOI: 10.1016/j.carbpol.2020.116764. IF JCR = 11.2, Q1.
- Iudin D., Zashikhina N., Demyanova E., Korzhikov-Vlakh V., Shcherbakova E., Boroznjak R., Tarasenko I., Zakharova N., Lavrentieva A., Skorik Y. and Korzhikova-Vlakh E. Polypeptide Self-Assembled Nanoparticles as Delivery Systems for Polymyxins B and E. Pharmaceutics 2020, 12, 868. https://www.mdpi.com/1999-4923/12/9/868. DOI: 10.3390/pharmaceutics12090868. IF JCR = 6.525, Q1.
- Korzhikov-Vlakh V., Tennikova T. (2021) Nanogels Capable of Triggered Release. In: Advances in Biochemical Engineering/Biotechnology. Springer, Berlin, Heidelberg. https://link.springer.com/chapter/10.1007/10_2021_163. (Глава в книге)IF JCR = 2.635
- Korzhikov-Vlakh V., Pepelanova I. (2021) Biological, Natural, and Synthetic 3D Matrices. pp 79-104 In: Kasper C., Egger D., Lavrentieva A. (eds) Basic Concepts on 3D Cell Culture. Learning Materials in Biosciences. Springer, Cham. https://link.springer.com/chapter/10.1007/978-3-030-66749-8_4 (Глава в книге. Учебник.)
- Polyakov, D.; Sinitsyna, E.; Grudinina, N.; Antipchik, M.; Sakhabeev, R.; Korzhikov-Vlakh, V.; Shavlovsky, M.; Korzhikova-Vlakh, E.; Tennikova, T. Polymer Particles Bearing Recombinant LEL CD81 as Trapping Systems for Hepatitis C Virus. Pharmaceutics. 2021, 13. https://www.mdpi.com/1999-4923/13/5/672, DOI: 10.3390/pharmaceutics13050672. IF JCR = 6.525, Q1.
- Mohamed A., Korzhikov-Vlakh V., Zhang N., Said A., Pilipenko I., Schäfer-Korting M., Zoschke C., Tennikova T. Effect of Poly(L-lysine) and Heparin Coatings on the Surface of Polyester-Based Particles on Prednisolone Release and Biocompatibility. Pharmaceutics. 2021; 13(6): 801. https://www.mdpi.com/1999-4923/13/6/801, DOI: 10.3390/pharmaceutics13060801. IF JCR = 6.525, Q1.
- Pilipenko I., Korzhikov-Vlakh V., Valtari A., Anufrikov Y., Kalinin S., Ruponen M., Krasavin M., Urtti A., Tennikova T. Mucoadhesive properties of nanogels based on stimuli-sensitive glycosaminoglycan-graft-pNIPAAm copolymers // International Journal of Biological Macromolecules. 2021. Vol. 186. P. 864–872. https://www.sciencedirect.com/science/article/pii/S0141813021015075?via%3Dihub, DOI: 10.1016/j.ijbiomac.2021.07.070. IF JCR = 8.025, Q1.
- Guryanov I., Korzhikov-Vlakh V., Bhattacharya M., Biondi B., Masiero G., Formaggio F., Tennikova T., Urtti A. Conformationally Constrained Peptides with High Affinity to the Vascular Endothelial Growth Factor // Journal of Medicinal Chemistry, 2021. 4, 15, 10900–10907 https://doi.org/10.1021/acs.jmedchem.1c00219 IF JCR = 8.039, Q1.
- Iudin D, Vasilieva M, Knyazeva E, Korzhikov-Vlakh V, Demyanova E, Lavrentieva A, Skorik Y, Korzhikova-Vlakh E. Hybrid Nanoparticles and Composite Hydrogel Systems for Delivery of Peptide Antibiotics. International Journal of Molecular Sciences. 2022; 23(5):2771. https://www.mdpi.com/1422-0067/23/5/2771,DOI: 10.3390/ijms23052771IF JCR = 6.208, Q1.
- Pilipenko I, Korovkina O, Gubina N, Ekimova V, Ishutinova A, Korzhikova-Vlakh E, Tennikova T, Korzhikov-Vlakh V. Random Copolymers of Lysine and Isoleucine for Efficient mRNA Delivery. International Journal of Molecular Sciences. 2022; 23(10):5363. https://www.mdpi.com/1422-0067/23/10/5363, DOI: 10.3390/ijms23105363IF JCR = 6.208, Q1.
- Averianov I., Stepanova M., Solomakha O., Gofman I., Serdobintsev M., Blum N., Kaftuirev A., Baulin I., Nashchekina J., Lavrentieva A., Vinogradova T., Korzhikov-Vlakh V., Korzhikova-Vlakh E. 3D-Printed Composite Scaffolds Based on Poly(ε-Caprolactone) Filled with Poly(Glutamic Acid)-Modified Cellulose Nanocrystals for Improved Bone Tissue Regeneration. Journal of Biomedical Materials Research: Part B - Applied Biomaterials. 2022, 110, 2422–2437, doi:10.1002/jbm.b.35100. IF JCR = 3.7, Q2.
- Averianov, I. V.; Stepanova, M.A.; Gofman, I. V.; Lavrentieva, A.; Korzhikov-Vlakh, V.A.; Korzhikova-Vlakh, E.G. Osteoconductive biocompatible 3D-printed composites of poly-d,l-lactide filled with nanocrystalline cellulose modified by poly(glutamic acid). Mendeleev Commun. 2022, 32, 810–812. https://www.sciencedirect.com/science/article/pii/S0959943622003224, DOI: 10.1016/J.MENCOM.2022.11.034. IF JCR = 1.837. Q3.
- Korovkina, O.; Polyakov, D.; Korzhikov-Vlakh, V.; Korzhikova-Vlakh, E. Stimuli-Responsive Polypeptide Nanoparticles for Enhanced DNA Delivery. Molecules 2022, 27, 8495. https://www.mdpi.com/1420-3049/27/23/8495, DOI: 10.3390/MOLECULES27238495 IF JCR = 4.927, Q1.
- Sinitsyna, E.; Bagaeva, I.; Gandalipov, E.; Fedotova, E.; Korzhikov-Vlakh, V.; Tennikova, T.; Korzhikova-Vlakh, E. Nanomedicines Bearing an Alkylating Cytostatic Drug from the Group of 1,3,5-Triazine Derivatives: Development and Characterization. Pharmaceutics 2022, 14, 2506. https://www.mdpi.com/1999-4923/14/11/2506, DOI: 10.3390/PHARMACEUTICS14112506. IF JCR = 6.525, Q1.
- Leonovich, M.; Korzhikov-Vlakh, V.; Lavrentieva, A.; Pepelanova, I.; Korzhikova-Vlakh, E.; Tennikova, T. Poly(lactic acid) and Nanocrystalline Cellulose Methacrylated Particles for Preparation of Cryogelated and 3D-Printed Scaffolds for Tissue Engineering. Polymers (Basel). 2023, 15, 651. https://www.mdpi.com/2073-4360/15/3/651, DOI: 10.3390/POLYM15030651. IIF JCR = 4.967, Q1.
- Sakhabeev, R.G.; Polyakov, D.S.; Sinitsyna, E.S.; Korzhikova-Vlakh, E.G.; Korzhikov-Vlakh, V.A.; Shavlovsky, M.M. Immune Response to the Introduction of Fibrillogenic β2-Microglobulin Protein Conjugated with Different Types of Polymer Particles. J. Evol. Biochem. Physiol. 2023, 59, 504–512. https://link.springer.com/article/10.1134/S0022093023020175 Scaffolds for Tissue Engineering. Polymers (Basel). 2023, 15, 651. https://www.mdpi.com/2073-4360/15/3/651, DOI: 10.3390/POLYM15030651. IIF JCR = 0.201, Q4.
- Dzhuzha, A.; Gandalipov, E.; Korzhikov-Vlakh, V.; Katernyuk, E.; Zakharova, N.; Silonov, S.; Tennikova, T.; Korzhikova-Vlakh, E. Amphiphilic Polypeptides Obtained by Post-Polymerization Modification of Poly-l-Lysine as Systems for Combined Delivery of Paclitaxel and siRNA. Pharmaceutics 2023, 15, 1308. https://www.mdpi.com/1999-4923/15/4/1308 DOI: 10.3390/PHARMACEUTICS15041308. IF JCR = 6.525, Q1.
- Vinogradova, T.I.; Serdobintsev, M.S.; Korzhikova-Vlakh, E.G.; Korzhikov-Vlakh, V.A.; Kaftyrev, A.S.; Blum, N.M.; Semenova, N.Y.; Esmedlyaeva, D.S.; Dyakova, M.E.; Nashchekina, Y.A.; etal. Comparison of Autografts and Biodegradable 3D-Printed Composite Scaffolds with OsteoconductiveProperties for Tissue Regeneration in Bone Tuberculosis. Biomedicines 2023, 11, 1–28. https://www.mdpi.com/2227-9059/11/8/2229, DOI: 10.3390/BIOMEDICINES11082229 IF JCR = 4.757, Q1.
- Stepanova, M.; Averianov, I.; Gofman, I.; Shevchenko, N.; Rubinstein, A.; Egorova, T.; Trulioff, A.; Nashchekina, Y.; Kudryavtsev, I.; Demyanova, E.; et al. Drug Loaded 3D-Printed Poly(ε-Caprolactone) Scaffolds for Local Antibacterial or Anti-Inflammatory Treatment in Bone Regeneration. Polymers (Basel). 2023, 15, 3957. https://www.mdpi.com/2073-4360/15/19/3957, DOI: 10.3390/polym15193957 IF JCR = 4.967, Q1.
- Zashikhina, N.; Gandalipov, E.; Dzhuzha, A.; Korzhikov-Vlakh, V.; Korzhikova-Vlakh, E. Dual drug loaded polypeptide delivery systems for cancer therapy. J. Microencapsul. 2023, 1–19. DOI: 10.1080/02652048.2023.2270064 IF JCR = 4.034, Q2.
- A.A. Belyaeva, A.S. Averchuk, N.A. Rozanova, O.P. Alexandrova, O.A. Solomakha, Y.A. Nashchekina, V.A. Korzhikov-Vlakh, S.O. Yurchenko, A.B. Salmina, E.G. Korzhikova-Vlakh, S.M. Morozova, Thermosensitiveinjectablefibrillargelsbasedoncellulosenanocrystalsgraftedwithpoly(N-isopropylacrylamide) asbiocompatiblebrainimplants, CarbohydratePolymers, V. 346, 2024, #122596 DOI: 10.1016/j.carbpol.2024.122596 IFJCR = 10.7, Q1.
- Leonovich, M.S., Korzhikov-Vlakh, V.A., Korzhikova-Vlakh, E.G. etal.Biocompatible Molecularly Imprinted Cryogel Matrices for Protein Recognition in Biological Samples. Polym. Sci. Ser. A, V.66, P.20–31 (2024)DOI: 10.1134/S0965545X24600479 IF JCR = 1.0, Q3.
- E.G. Korzhikova-Vlakh, N.N. Zashikhina, E.G. Stulova, A.Yu. Dzhuzha, V.A. Korzhikov-Vlakh, Effect of L- or D,L-leucine content on self-assembly and properties of its amphiphilic copolymers with L-lysine, Mendeleev Communications, V.34, I.3, 2024, P. 365-368.DOI: 10.1016/j.mencom.2024.04.017. IF JCR = 1.8, Q3.
- Sakhabeev, R.G., Polyakov, D.S., Sinitsyna, E.S. et al. Features of the Humoral Immune Response When Using Protein Immobilized on the Surface of Nano- and Microparticles Based on Poly(Lactic Acid). J EvolBiochem Phys60, 466–475 (2024). DOI: 10.1134/S0022093024020030 IF JCR = 0.6
- Sakhabeev, R. G., Polyakov, D. S., Korzhikov-Vlakh, V. A., Sinitsyna, E. S., Platonova, G. A., Korzhikova-Vlakh, E. G., &Shavlovsky, M. M. (2024). Effect of the size of polymer particles bearing protein antigen on the in vivo T-cellular immune response. Cellular Therapy and Transplantation, 13(1), 42–48. DOI: 10.18620/ctt-1866-8836-2024-13-1-42-48 IF JCR = 0.5, Q4