Laboratory of Biomedical Chemistry
Biofunctional Scaffolds for Tissue Engineering
Group members
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Group leader Viktor Korzhikov-VlakhPhD, Associate Professor |
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Ekaterina SinitsynaPhD, Senior Researcher |
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Mariia KrylovaPhD student |
Collaboration
- Prof. MD Mikhail Serdobintsev (Department of Phthysioosteology and orthopaedy) and Prof. MD Tatiana Vinogradova (Laboratory of experimental tuberculosis and new medical technologies), Institute of Phthisiopulmonology RAS;
- Prof. Thomas Scheper and Dr. Antonina Lavrentieva, Institute of Technical Chemistry Leibniz University of Hannover;
- Laboratory of polymer carriers and sorbents for biotechnology and Laboratory of polymer biomaterials and systems Institute of Macromolecular Compounds RAS.
Directions of Research
- supermacroporous matrices based on polymers of different nature to be used as scaffold for tissue engineering;
- 3D-printing of complex polymer materials;
- modification of the polymeric materials surface with biomolecules of different nature and functionality in order to regulate cells adhesion, migration, proliferation and differentiation;
- construction of scaffolds, which are able to release growth factors and anti-inflammatory agents in a controlled manner;
- in vitro and in vivo testing of the obtained materials.
3D printer GeSim BioScaffolder® in the Laboratory of polymer biomaterials and systems at the Institute of Macromolecular Compounds RAS
Projects
- Participation into the project «Development of biocompatible materials based on chemically modified cellulose» within Megagrant of Russian Government (agreement № 14.W03.31.0014). The Laboratory within this Megagarnt is headed by Prof. Dr. Mikko Karttunen.
- RSF-DFG grant application together with the Institute of Technical Chemistry at Leibniz University of Hannover. The grant theme is “Biodegradable scaffolds for bone tissue engineering: materials with adjustable mechanical and biofunctional properties, capable of controlled release of osteogenic factors”.
Publications
- Averianov I., Korzhikov-Vlakh V.A., Moskalenko Yu., Smirnova V., Tennikova T. One-pot synthesis of poly(lactic acid) with terminal methacrylate groups for the adjustment of mechanical properties of biomaterials. Mendeleev Communications. 2017. V. 27. P.574-576.
- Korzhikov-Vlakh V., Averianov I., Sinitsyna E., Nashchekina Y., Polyakov D., Guryanov I., Lavrentieva A., Raddatz L., Korzhikova-Vlakh E., Scheper T., Tennikova T. Novel pathway for efficient covalent modification of polyester materials of different design to prepare biomimetic surfaces. Polymers (Basel). 2018. 10.
- Averianov I.V., Stepanova M.A., Gofman I.V., Nikolaeva A.L., Korzhikov-Vlakh V.A., Karttunen M., Korzhikova-Vlakh E.G. Chemical modification of nanocrystalline cellulose for enhanced interfacial compatibility with poly(lactic acid). Mendeleev Communications. 2019. V.29. P.220-222.