Research Groups

Department of Physical Organic Chemistry
Rooms 3186 (office), 3193 (lab)

Noncovalent Organocatalysis

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In the past decade, organocatalysis has been the focus of extensive studies owing to its significant advantages over catalysis by metal-containing species including lower toxicity, reduced environmental footprint, and low to negligible sensitivity to air and moisture. In general, organocatalysts can function either through a covalent or noncovalent bonding activation. A covalent activation mode involves the formation of covalent bond(s) between a substrate and catalyst, whereas a noncovalent mode involves the activation of substrates through noncovalent linkages to the catalyst. For noncovalent catalysis, an organic catalyst typically interacts with a substrate through hydrogen bonding, whereas catalytic reactions involving halogen or chalcogen bonding are far less explored.